Toothache Medicine for Adults: Top 10 Reviews
Discover the top 10 toothache medicines for adults, including OTC pain relievers, prescription options, and natural remedies. Read expert reviews to find fast, effective relief for tooth pain and improve your oral comfort.

Toothaches can be excruciating, disrupting daily activities like eating, speaking, or even sleeping. Whether caused by cavities, gum disease, or dental injuries, finding the right medicine is essential for quick relief. This blog reviews the top 10 toothache medicines for adults, including over-the-counter (OTC) options, prescription drugs like Tapentadol Hydrochloride 100 mg, and natural remedies, to help you choose the best solution for your dental pain.
Top 10 Toothache Medicines for Adults
Here’s a curated list of the most effective medications and remedies for toothache relief, based on efficacy, accessibility, and user feedback:
-
Ibuprofen (Advil, Motrin)
- Type: OTC NSAID
- Use: Reduces pain and inflammation from toothaches caused by swelling or gum issues.
- Dosage: 200-400 mg every 4-6 hours, not exceeding 3200 mg daily.
- Pros: Fast-acting, widely available, reduces swelling.
- Cons: May cause stomach irritation if taken long-term.
-
Acetaminophen (Tylenol)
- Type: OTC Analgesic
- Use: Relieves mild to moderate tooth pain without addressing inflammation.
- Dosage: 500-1000 mg every 4-6 hours, up to 4000 mg daily.
- Pros: Gentle on the stomach, safe for most adults.
- Cons: Doesn’t reduce swelling, less effective for severe pain.
-
Tapentadol Hydrochloride 100 mg (Nucynta)
- Type: Prescription Opioid
- Use: For severe tooth pain unresponsive to OTC drugs, often post-dental surgery.
- Dosage: Typically 50-100 mg every 4-6 hours, as prescribed.
- Pros: Powerful pain relief for intense toothaches.
- Cons: Risk of dependency, side effects like nausea or drowsiness. Requires medical supervision.
-
Aspirin
- Type: OTC NSAID
- Use: Reduces mild tooth pain and inflammation.
- Dosage: 325-650 mg every 4 hours, not exceeding 4000 mg daily.
- Pros: Affordable, effective for mild pain.
- Cons: Not suitable for those with bleeding disorders or stomach issues.
-
Benzocaine (Orajel)
- Type: OTC Topical Anesthetic
- Use: Numbs the affected area for temporary relief.
- Dosage: Apply a small amount to the painful tooth/gum up to 4 times daily.
- Pros: Fast localized relief, easy to apply.
- Cons: Short-lasting, may cause irritation in some users.
-
Clove Oil (Eugenol)
- Type: Natural Remedy
- Use: Applied to the tooth for its natural numbing and antiseptic properties.
- Dosage: Dilute with a carrier oil and apply sparingly with a cotton swab.
- Pros: Natural, widely available, reduces inflammation.
- Cons: Strong taste, potential for gum irritation if overused.
-
Naproxen (Aleve)
- Type: OTC NSAID
- Use: Long-lasting relief for moderate tooth pain and inflammation.
- Dosage: 220-440 mg every 8-12 hours, not exceeding 660 mg daily.
- Pros: Longer duration than ibuprofen, effective for swelling.
- Cons: May cause gastrointestinal side effects.
-
Lidocaine Gel
- Type: OTC Topical Anesthetic
- Use: Provides numbing relief for tooth or gum pain.
- Dosage: Apply a thin layer to the affected area up to 4 times daily.
- Pros: Stronger numbing than benzocaine, quick-acting.
- Cons: Temporary relief, not for deep-rooted pain.
-
Codeine (Prescription)
- Type: Prescription Opioid
- Use: For moderate to severe tooth pain, often combined with acetaminophen.
- Dosage: 15-60 mg every 4-6 hours, as prescribed.
- Pros: Effective for post-procedure pain.
- Cons: Risk of sedation, dependency, and constipation.
-
Antibiotics (e.g., Amoxicillin)
- Type: Prescription
- Use: Treats toothaches caused by bacterial infections, like abscesses.
- Dosage: Typically 500 mg every 8 hours for 5-7 days, as prescribed.
- Pros: Addresses infection-related pain.
- Cons: Doesn’t directly relieve pain, requires dental follow-up.
Prescription Medications: When to Consider Them
For severe toothaches, such as those caused by abscesses or post-surgical pain, prescription medications may be necessary:
- Tapentadol Hydrochloride 100 mg: This opioid is reserved for intense pain when OTC options fail. It works by altering pain perception in the brain, offering relief within 30-60 minutes. Due to risks of dependency and side effects like dizziness or nausea, it should only be used under a dentist’s or doctor’s guidance.
- Corticosteroids: Occasionally prescribed for inflammation-related tooth pain, though less common.
- Antibiotics: Essential for infection-related toothaches but must be paired with dental treatment to address the root cause.
Always consult a healthcare provider before using prescription drugs, and never self-medicate.
Complementary Remedies for Toothache Relief
In addition to medications, these approaches can enhance relief:
- Saltwater Rinse: Mix 1 tsp of salt in warm water and rinse for 30 seconds to reduce bacteria and swelling.
- Cold Compress: Apply to the cheek for 15 minutes to numb pain and reduce inflammation.
- Dental Visit: Most toothaches require professional treatment, like fillings or root canals, to address the underlying issue.
Precautions When Using Toothache Medicines
- Follow Dosage Guidelines: Overusing NSAIDs or opioids like Tapentadol Hydrochloride 100 mg can lead to serious side effects, including liver damage or dependency.
- Avoid Prolonged Use: OTC and topical treatments are for short-term relief. Persistent pain requires a dentist’s evaluation.
- Check Allergies: Ensure you’re not allergic to ingredients like benzocaine or clove oil before use.
- See a Dentist: Toothaches often signal underlying issues like cavities or infections that medications only temporarily mask.
FAQs About Toothache Medicines for Adults
Q: How fast does Tapentadol Hydrochloride 100 mg work for tooth pain?
A: It typically provides relief within 30-60 minutes, but its use should be strictly monitored by a healthcare provider due to potential side effects.
Q: Can I combine ibuprofen and benzocaine for toothache relief?
A: Yes, but only under medical guidance to avoid overuse or interactions. They target different aspects of pain (inflammation vs. numbing).
Q: Are natural remedies like clove oil effective for toothaches?
A: Clove oil can provide temporary relief due to its numbing properties, but it’s not a substitute for dental treatment.
Q: When should I see a dentist for a toothache?
A: Visit a dentist if pain lasts more than 1-2 days, worsens, or is accompanied by swelling, fever, or difficulty chewing.